This research examines the Canadian National Fire Information Database (NFID) to understand more about At Risk Populations (Area of Focus #5 as per the Request for Proposal documentation). The broad focus was to explore what we know about fire-related casualties in Canada and what the protective influences of working life safety systems are. The analysis focused on residential structure fires reported to the NFID between 2005 and 2015, reported by Alberta, British Columbia, Manitoba, Ontario, and Saskatchewan. With a focus on non-firefighter casualties, the sample of residential fires included 830 deaths and 4,656 injuries.